神经节苷脂糖

Ganglioside sugars (Ganglio-Series) 神经节苷脂糖
神经节苷脂是复杂的鞘糖脂（简称GSL，也被称为糖脂），包含唾液酸。它们是脊椎动物细胞膜的建构单元， 在细胞到细胞和细胞到细胞外基质（毒素，激素，病毒的受体……）通信时发挥关键作用。 作为肿瘤发病机制的一部分，这些分子算是疫苗的进攻目标。
神经节苷脂糖系统命名法:
G代表神经节苷脂
M, D, T & Q分别代表单个，两个，三个，四个唾液酸
1，2，3为薄层色谱中距离迁移的顺序

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Modified from Essentials of Glycobiology 2nd Edition, Varki A, Cummings RD, Esko JD, et al., editors. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
J. Heimburg-Molinaro et al., Vaccine 29 (2011) 8802-8826.
S. Hakomori. Biochimica etBiophysica Acta 1780 (2008) 325-346.
上海甄准生物提供神经节苷脂糖，原装进口，咨询/订购热线：400-002-3832
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规格: 5 mg, 25 mg, 100 mg, 1 g, 5 g
EOT-GLY090

GM3神经节苷脂糖/ 3'-唾液酸乳糖
GM3 Ganglioside sugar
3'Sialyllactose

Neu5Acα2-3Galβ1-4Glc
C23H38NO19Na FW 655.53
[35890-38-1]


Human Milk Oligosaccharide Kunz et al., 2000. Ann Rev Nutr 20, 699-722
Product provided for the following study: “Chemoenzymatic synthesis of GM3 and GM2 gangliosides containing a truncated ceramide functionalized for glycoconjugate synthesis and solid phase applications”. Jacques S et al,. 2006. Org Biomol Chem. 2006 Jan 7;4(1):142-54
EOT-GLY091

GD3神经节苷脂糖/ 二唾液酸乳糖
GD3 Ganglioside sugar
Disialyl lactose / DS-L

Neu5Acα2-8Neu5Acα2-3Galβ1-4Glc C34H54N2O27Na2 FW 968.76


Tumor-associated carbohydrate antigen (TACA) Birkle S et al. 2003. Biochimie. 85(3-4): 455-63
Bovine Milk & Colostrum P. K. Gopal et al. British Journal of Nutrition (2000), 84, Suppl 1, S69-S74
EOT-GLY092

GT3神经节苷脂糖/ 三唾液酸乳糖
GT3 Ganglioside sugar
Trisialyl lactose

Neu5Acα2-8Neu5Acβ2-8Neu5Acα2-3Galβ1-4Glc
C45H70N3O35Na3 FW 1282.00
EOT-GLY105

GQ3神经节苷脂糖/ 四唾液酸乳糖
GQ3 Ganglioside sugar
Quadrisialyl lactose

Neu5Acα2-8Neu5A