研发生产盐酸帕洛诺司琼 盐酸帕拉诺司琼CAS: 135729-62-3原料供应厂家品质保障现货直销

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中文名盐酸帕洛诺司琼英文名Palonosetron Hydrochloride别名盐酸帕洛诺司琼盐酸帕拉诺司琼盐酸帕洛诺司琼注射液盐酸帕洛诺司琼对照品盐酸帕洛诺司琼杂质3盐酸帕洛诺司琼杂质2盐酸帕洛诺司琼, 一种 5-HT3拮抗剂(3aS)-2-[(3s)-1-氮杂双环[2.2.2]辛烷基-2,3,3a,4,5,6-六氢-1-氧代-1H-苯并[de]异喹啉盐酸盐英文别名CS-292PALonOSETRON HCLPalonosetron HclPalonosetron-d3 HClPalonosetron HCl(SR)Palonosetron HCl(RR)Palonosetron HCl(RS)PALonOSETRON HYDROCHLORIDEPalonosetron HydrochloridePalonosetron. Hydrochloride(S,S)-Palonosetron Hydrochloride(S)-2-((S)-quinuclidin-3-yl)-2,3,3a,4,5Palonosetronhydrochloride hydrochloride(3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride(3aS)-2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride(3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one monohydrochlorideCAS135729-62-3EINECS680-630-6化学式C19H25ClN2O分子量332.87InChIInChI=1/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/m1./s1熔点>290°C沸点470.4°C at 760 mmHg比旋光度D25 -94.1° (c = 0.4 in water)闪点209.5°C蒸汽压5.07E-09mmHg at 25°C溶解度Methanol (Slightly, Heated), Water (Slightly)存储条件Inert atmosphere,Store in freezer, under -20°C敏感性Sensitive to heat外观Solid颜色White to Off-WhiteMerck14,6997MDL号MFCD00939524体外研究Palonosetron 是一种高效高选择性的第二代5-HT3 受体拮抗剂，对5-HT3受体的结合亲和性比其它5-HT3受体拮抗剂高100倍(Palonosetron pK i 10.5，而 granisetron pK i 8.91， tropisetron pK i 8.81 ，ondansetron pK i 8.39, dolasetron pK i 7.6). Palonosetron血浆半衰期比同种类拮抗剂长，约为40 小时 (ondansetron, 4小时; tropisetron, 7.3 小时; dolasetron, 7.5 小时; ranisetron, 8.9小时)。