研发生产低分子肝素 盐酸甲哌卡因 盐酸卡波卡因CAS: 1722-62-9原料供应仅供出口现货直销

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中文名盐酸卡波卡因英文名mepivacaine hydrochloride别名低分子肝素盐酸甲哌卡因盐酸卡波卡因甲哌卡因杂质B甲哌卡因盐酸盐盐酸甲哌卡因(碱基)盐酸甲哌卡因?, BR盐酸甲哌卡因, 局部麻醉, 电压门控NA+通道阻滞剂N-(2,6-二甲基苯基)-1-甲基-2-哌啶甲酰胺盐酸盐英文别名Mepivacaine HCLMepivacaine HCl USPcarbocainehydrochloridemepivacaine hydrochloridedl-mepivacainehydrochlorideRopivacaine base Mepivacaine HCLMepivacaine Hydrochloride (200 mg)1-methyl-2',6'-pipecoloxylididehydrochloride1-methyl-2',6'-pipecoloxylididehydrochloride1-methyl-2',6'-pipecoloxylidine hydrochloridedl-1-methyl-2',6'-pipecoloxylididehydrochloride6'-pipecoloxylidide,1-methyl-2monohydrochloride2',6'-Pipecoloxylidide, 1-methyl-, monohydrochloride (6CI, 8CI)n-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamide hydrochloriden-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamidmonohydrochloride(1-methyl-dl-piperidine-2-carboxylicacid)-2,6-dimethylanilidehydrochloride2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride (9CI)CAS1722-62-9EINECS217-023-9化学式C15H22N2O.ClH分子量282.81InChIInChI=1/C15H22N2O.ClH/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3;/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);1H熔点255-257°C (dec.)沸点383.1°C at 760 mmHg闪点185.5°C蒸汽压4.52E-06mmHg at 25°C溶解度H2O: soluble20mg/mL, clear存储条件2-8°C外观powder颜色white to beige体外研究Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action. Mepivacaine hydrochloride has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine). Mepivacaine hydrochloride displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels.体内研究对马的测试表明，与根据以前解剖的，乳胶注射后得到的假定相比，mepivacaine在相邻关节结构间具有更大的扩撒，与关节造影研究形成对比。经历膝关节镜检查患者中，与神经刺激相比较，超声处理使1.5% mepivacaine阻断坐骨神经所需的最低有效麻醉剂体积(MEAV50)减少37%。在犬齿和前臼齿中，lidocaine制剂与肾上腺素相比，3%mepivacaine的使用使麻醉时间间隔更短。