研发生产圣草酚CAS: 552-58-9原料药研发供应中间体现货直销

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中文名圣草酚英文名(S)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4-benzopyrone别名圣草酚毛纲草酚(S)-圣草酚圣草酚(标准品)毛纲草酚对照品,圣草酚, 来源于柠檬3',4',5,7-四羥二氫黃酮(S)-2-(3,4-二羟基苯基)-2,3-二氢-5,7-二羟基-4-香豆素英文别名EriodictyolERIODICTYOLERIODICTYOL(SH)5,7,3',4'-TETRAHYDROXYFLAVANONE3',4',5,7-tetrahydroxyflavanone3',4',5,7-TETRAHYDROXYFLAVANONE(S)-3',4',5,7-TETRAHYDROXYFLAVANONE(2S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chroman-4-one2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydro-4H-chromen-4-one(S)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4-benzopyrone2-[3,4-DIHYDROXYPHENYL]2,3-DIHYDRO-5,7-DIHYDROXY-4H-1BENZOPYRAN-4-ONE4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-CAS552-58-9EINECS209-016-4化学式C15H12O6分子量288.25InChIInChI=1/C15H12O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-5,13,16-19H,6H2InChIKeySBHXYTNGIZCORC-ZDUSSCGKSA-N密度1.586±0.06 g/cm3(Predicted)熔点270°C沸点625.2±55.0 °C(Predicted)闪点241.9°C水溶性70mg/L(20 ºC)蒸汽压3.19E-16mmHg at 25°CJECFA Number2172溶解度DMSO (Slightly), Methanol (Very Slightly)折射率1.724酸度系数7.49±0.40(Predicted)存储条件2-8°C稳定性Hygroscopic外观neat颜色White to Pale BeigeBRN5104930物化性质易溶于甲醇,略微溶于沸水、热乙醇、yimi及冰醋酸,溶于稀碱。 来源于田麻科植物圣草MDL号MFCD00017312体外研究Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol (20, 40, 80 μM) protects primary cultured cortical neurons against Aβ 25-35 -induced cytotoxicity and cell apoptosis via the Nrf2/ARE pathway. Eriodictyol (80 μM) induces nuclear expression of Nrf2 and the expression of ARE-regulated genes in primary cultured cortical neurons.体内研究Eriodictyol shows protective effect against LPS-induced acute lung injury (ALI). Eriodictyol (30 mg/kg, p.o.) decreases the production of inflammatory cytokines, elevates survival rate, and decreases oxidative stress levels in LPS-induced ALI mice. Eriodictyol inhibits MPO activity and inflammatory neutrophil accumulation in the lung tissues. Eriodictyol treatment also enhances Trx1 expression by upregulating the Nrf2 expression in lung tissues.